Oocyte-secreted factors: regulators of cumulus cell function and oocyte quality
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چکیده
منابع مشابه
Oocyte-secreted factors: regulators of cumulus cell function and oocyte quality.
Oocyte quality is a key limiting factor in female fertility, yet we have a poor understanding of what constitutes oocyte quality or the mechanisms governing it. The ovarian follicular microenvironment and maternal signals, mediated primarily through granulosa cells (GCs) and cumulus cells (CCs), are responsible for nurturing oocyte growth, development and the gradual acquisition of oocyte devel...
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Background: In vitro maturation is a good method to decrease cancer risk of superovulation by gonadotropin hormones. A paracrine effect of oocyte secretions on oocyte developmental competence is under investigation. Apart from oocyte maturation, ovulation in vivo requires a precise control of extracellular matrix modification. Cumulus cells secrete hyaluronan to form a muco-elastic extracellula...
متن کاملImmature oocyte quality and maturational competence of porcine cumulus-oocyte complexes subpopulations.
Porcine immature oocyte quality (i.e., that of live oocytes at the germinal vesicle stage) was evaluated according to features of the surrounding cumulus, aiming to establish maturational competence of different subpopulations of such cumulus-oocyte complexes. Six subpopulations were identified: A1 (with a dense cumulus), A2 (with a translucent cumulus), B1 (with the corona radiata), B2 (partly...
متن کاملGene Expression in Cumulus Cells and Oocyte Quality
A.R. Genazzani, B.C. Tarlatzis (eds.), Frontiers in Gynecological Endocrinology: Volume 3: Ovarian Function and Reproduction From Needs to Possibilities, ISGE Series, DOI 10.1007/978-3-319-23865-4_5 P.G. Artini Division of Gynecology and Obstetrics, Department of Experimental and Clinical Medicine, University of Pisa, Pisa, Italy e-mail: [email protected] 5 Gene Expression in Cumulus Ce...
متن کاملInfluence of oocyte-secreted factors and culture duration on the metabolic activity of bovine cumulus cell complexes.
Intracellular communication between the cumulus cell complex and the oocyte is essential for numerous processes during oocyte maturation. The aim of this study was to determine the interaction between oocyte-secreted factors and the metabolic activity of bovine cumulus cell complexes during in vitro maturation (IVM). Cumulus-oocyte complexes (COCs) were aspirated from ovaries derived from an ab...
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ژورنال
عنوان ژورنال: Human Reproduction Update
سال: 2008
ISSN: 1460-2369,1355-4786
DOI: 10.1093/humupd/dmm040